High-Throughput Mass Spectrometry in Drug Discovery Apply mass spectrometry to every phase of new drug discovery with this cutting-edge guide Mass spectrometry is a technique that identifies and characterizes compounds based on their mass — the fundamental molecular characteristic. It has become an invaluable analytical tool in various disciplines, industries, and research fields. It has become particularly central to new drug discovery and development, which broadly deploys mass spectrometry at every phase. The pharmaceutical industry has become one of the main drivers of technological development in mass spectrometry. High-Throughput Mass Spectrometry in Drug Discovery offers a comprehensive introduction to mass spectrometry and its applications in pharmaceutical discovery. It covers the foundational principles and science of mass spectrometry before moving to specific experimental methods and their applications at various stages of drug discovery. Its thorough treatment and detailed guidance make it an invaluable tool for pharmaceutical research and development. High-Throughput Mass Spectrometry in Drug Discovery readers will also find: Detailed analysis of techniques, including label-free screening, synthetic reaction optimization, and more An authorial team with extensive combined experience in research and industrial applications Technical strategies with the potential to accelerate quantitative bioanalysis in drug discovery High-Throughput Mass Spectrometry in Drug Discovery is essential for analytical, bioanalytical, and medicinal chemists working in the pharmaceutical industry and for any researchers and graduate students interested in drug discovery and development.

The book offers an in-depth research of the economic situations along the Belt and Road and the initiative's cooperation prospects, opportunities and challenges. It draws on economic data, including those on trade, investment, infrastructure, urban distribution, industrial cooperation, financial integration and revision of historical and political background. The Belt and Road initiative (BRI) comes from not only the ancient Silk Road, but also a long-term international cooperation between China and relevant countries. As a China-led initiative, the BRI is built upon China's international vision according to its development process. Therefore, the book also discusses how China balances its own development process among different domestic regions, and how the Initiative fits into the changes of global economic system and brings positive change for developing and developed economies involved, on the long haul. Furthermore, this book aims to find out precise direction of the initiative in order to assess appropriate implication on development under current globalization and provide valuable experience for future economic synergetic development by reviewing the past cooperative experience as references for policy-making and prospective engagementIn terms of methodology, analyses were conducted applying multi-methods with best available evidence to enrich the understanding of the potential of the BRI in terms of socio-economic impact on cooperation and difference and similarities of economic, cultural characteristics and political system among countries.

This book mainly addresses China's Belt and Road Initiative in terms of the connectivity industrial and spatial development, as well as current world's economic and trade pattern under such synergy development, and focuses on the function and mechanism of industry and geography coordination. Although current research on the value circulation between China and developed economies is relatively adequate, the book focuses on the value circulation between the countries and regions, especially the developing economies. China and other developing countries tie strongly with the production value circulation. The coordination industrial and spatial development in the global value cycle is also the cornerstone of long-term stabilization and sustainable development in China. Therefore, this book provides the theoretical and empirical research on Belt and Road from the perspectives on industrial and spatial synergy. This book proposes several questions: Any inherent inlay between industrial and geographic allocation, i.e., is there any possibility for close integration? This book analyzes the necessity of coordinated development of industry and space perspective of production division. Secondly, from the perspective of historical evolution and current situation, it analyzes the relationship among industry, economic growth and fluctuation and compares realizing paths of synergy of industrial and spatial development. It contains the industry and spatial diffusion mechanism and the effect of synergy development. Moreover, the corresponding policy implication is provided for sustainable development through the Belt and Road Initiative.

This book systemically presents the latest research on renal fibrosis, covering all the major topics in the field, including the possible mechanisms, biomarkers, and strategies for prevention and treatment of chronic kidney disease (CKD). Due to its high prevalence, CKD represents a huge global economic and social burden. Irrespective of the initial causes, CKD progresses to end stage kidney disease (ESKD) due to renal fibrosis, which is characterized by glomerulosclerosis, tubule atrophy and atresia, and the excessive accumulation of extracellular matrix (ECM) in the kidney. Unfortunately, an estimated 1%-2% of the adult population living with CKD will need renal replacement therapy at some point as a result of ESKD. As such, strategies for preventing or slowing CKD progression to ESKD are of utmost importance, and studies aiming to understand the mechanisms of renal fibrosis have been the focus of intensive research. Recently, novel insights into the pathophysiological processes have furthered our understanding of the pathogenesis of renal fibrosis, and more importantly, promoted studies on the early diagnosis and treatment of CKD. This book draws lessons from the extensive, state-of-the-art research in this field, elaborating the new theories and new techniques to offer readers a detailed and comprehensive understanding of renal fibrosis and as well as inspiration for future research directions.

The book offers an in-depth research of the economic situations along the Belt and Road and the initiative's cooperation prospects, opportunities and challenges. It draws on economic data, including those on trade, investment, infrastructure, urban distribution, industrial cooperation, financial integration and revision of historical and political background. The Belt and Road initiative (BRI) comes from not only the ancient Silk Road, but also a long-term international cooperation between China and relevant countries. As a China-led initiative, the BRI is built upon China's international vision according to its development process. Therefore, the book also discusses how China balances its own development process among different domestic regions, and how the Initiative fits into the changes of global economic system and brings positive change for developing and developed economies involved, on the long haul. Furthermore, this book aims to find out precise direction of the initiative in order to assess appropriate implication on development under current globalization and provide valuable experience for future economic synergetic development by reviewing the past cooperative experience as references for policy-making and prospective engagementIn terms of methodology, analyses were conducted applying multi-methods with best available evidence to enrich the understanding of the potential of the BRI in terms of socio-economic impact on cooperation and difference and similarities of economic, cultural characteristics and political system among countries.

This book constitutes the refereed proceedings of the 25th Australasian Conference on Information Security and Privacy, ACISP 2020, held in Perth, WA, Australia, in November 2020*. The 31 revised full papers and 5 short papers presented were carefully revised and selected from 151 submissions. The papers present and discuss the latest research, trends, breakthroughs, and challenges in the domain of information security, privacy and cybersecurity on a variety of topics such as post-quantum cryptography; symmetric cipher; signature; network security and blockchain; cryptographic primitives; mathematical foundation; machine learning security, among others. *The conference was held virtually due to COVID-19 pandemic.

This book systemically presents the latest research on renal fibrosis, covering all the major topics in the field, including the possible mechanisms, biomarkers, and strategies for prevention and treatment of chronic kidney disease (CKD). Due to its high prevalence, CKD represents a huge global economic and social burden. Irrespective of the initial causes, CKD progresses to end stage kidney disease (ESKD) due to renal fibrosis, which is characterized by glomerulosclerosis, tubule atrophy and atresia, and the excessive accumulation of extracellular matrix (ECM) in the kidney. Unfortunately, an estimated 1%-2% of the adult population living with CKD will need renal replacement therapy at some point as a result of ESKD. As such, strategies for preventing or slowing CKD progression to ESKD are of utmost importance, and studies aiming to understand the mechanisms of renal fibrosis have been the focus of intensive research. Recently, novel insights into the pathophysiological processes have furthered our understanding of the pathogenesis of renal fibrosis, and more importantly, promoted studies on the early diagnosis and treatment of CKD. This book draws lessons from the extensive, state-of-the-art research in this field, elaborating the new theories and new techniques to offer readers a detailed and comprehensive understanding of renal fibrosis and as well as inspiration for future research directions.